- clinical trial (CTIMP) or administration of an unlicensed drug
- ionising radiation
- collection of cellular tissue samples subject to the Human Tissue Act
- DNA/RNA used in a new study without donor consent
- adults lacking capacity to consent
- use of certain medical devices
- participants recruited by virtue of being UK National Health Service (NHS) patients
- NHS staff5 or NHS data3
- use of organs or other bodily material of past or present NHS patients
- class A invasive procedure (defined in CUREC glossary)
If the research involves any of the above, it will require sponsorship review.
Research involving healthy volunteers and/or NHS staff, and no collection of tissue subject to the Human Tissue Act, will then be considered by the relevant CUREC subcommittee.
Other research will be subject to NHS ethics review via the Health Research Authority.
If the research doesn't involve any of these, apply to the relevant CUREC subcommittee.